Difference between revisions of "BslA"
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| − | * '''Description:''' amphiphilic protein, forms water-repellent surface layer of the biofilm<br/><br/> | + | * '''Description:''' amphiphilic protein, forms water-repellent surface layer of the biofilm, inhibitor of [[KinA]] autophosphorylation, and subsequently of entry into [[sporulation]] <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|''bslA'' | |''bslA'' | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yuaB '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yuaB, sivB '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || biofilm surface layer | + | |style="background:#ABCDEF;" align="center"| '''Product''' || biofilm surface layer, inhibitor of [[KinA]] autophosphorylation |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || [[biofilm formation]] | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[biofilm formation]], control of entry into [[sporulation]] via the [[phosphorelay]] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 9.987 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 9.987 | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
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| − | |||
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| − | |||
<br/><br/> | <br/><br/> | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[biofilm formation]]}} | + | {{SubtiWiki category|[[biofilm formation]]}}, |
| + | {{SubtiWiki category|[[phosphorelay]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** inhibits [[KinA]] autophophorylation {{PubMed|23335417}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
| − | * '''Paralogous protein(s):''' [[ | + | * '''Paralogous protein(s):''' [[SivA]] |
=== Extended information on the protein === | === Extended information on the protein === | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed] | ** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed] | ||
** biofilm matrix in an extracellular polysaccharide-dependent manner {{PubMed|22571672}} | ** biofilm matrix in an extracellular polysaccharide-dependent manner {{PubMed|22571672}} | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yuaB_3187503_3188048_1 yuaB] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yuaB_3187503_3188048_1 yuaB] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 11:55, 1 February 2013
- Description: amphiphilic protein, forms water-repellent surface layer of the biofilm, inhibitor of KinA autophosphorylation, and subsequently of entry into sporulation
| Gene name | bslA |
| Synonyms | yuaB, sivB |
| Essential | no |
| Product | biofilm surface layer, inhibitor of KinA autophosphorylation |
| Function | biofilm formation, control of entry into sporulation via the phosphorelay |
| MW, pI | 19 kDa, 9.987 |
| Gene length, protein length | 543 bp, 181 aa |
| Immediate neighbours | gbsR, ktrA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biofilm formation, phosphorelay
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31080
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Protein family:
- Paralogous protein(s): SivA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P71014
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- Physpank-yuaB based on vector pDR111: pDRyuaB2 PubMed
- lacZ fusion:
- pNW500 PyuaB-lacZ fusion in pDG1663 PubMed
- GFP fusion:
- PyuaB-gfp fusion in pSG1151 vector: pSGyuaB PubMed
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
Additional publications: PubMed
