Difference between revisions of "RecX"
| Line 37: | Line 37: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[DNA repair/recombination]]}} | + | {{SubtiWiki category|[[DNA repair/ recombination]]}} |
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| Line 49: | Line 49: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * reduced natural tranformation with plasmid or chromosomal DNA {{PubMed|23284295}} | ||
=== Database entries === | === Database entries === | ||
| Line 57: | Line 58: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| Line 66: | Line 65: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | + | ** modulates the "length or packing" of a [[RecA]] filament, thereby [[RecX]] facilitates the initiation of recombination and increases recombination across species {{PubMed|23284295}} | |
* '''Protein family:''' recX family (according to Swiss-Prot) | * '''Protein family:''' recX family (according to Swiss-Prot) | ||
| Line 86: | Line 85: | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
| − | ** | + | ** forms foci on the nucleoid upon DNA damage {{PubMed|23284295}} |
| + | ** forms foci at the cells poles and/ or the nucleoid upon induction of genetic competence {{PubMed|23284295}} | ||
=== Database entries === | === Database entries === | ||
Revision as of 13:17, 4 January 2013
- Description: recombination protein, modulates the SOS response and facilitates RecA-mediated recombinational repair and genetic recombination
| Gene name | recX |
| Synonyms | yfhG |
| Essential | no |
| Product | recombination protein |
| Function | DNA repair/recombination |
| Gene expression levels in SubtiExpress: recX | |
| MW, pI | 30 kDa, 6.292 |
| Gene length, protein length | 792 bp, 264 aa |
| Immediate neighbours | yfhF, yfhH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU08520
Phenotypes of a mutant
- reduced natural tranformation with plasmid or chromosomal DNA PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: recX family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31575
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Paula P Cárdenas, Begoña Carrasco, Clarisse Defeu Soufo, Carolina E César, Katharina Herr, Miriam Kaufenstein, Peter L Graumann, Juan C Alonso
RecX facilitates homologous recombination by modulating RecA activities.
PLoS Genet: 2012, 8(12);e1003126
[PubMed:23284295]
[WorldCat.org]
[DOI]
(I p)
Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849]
[WorldCat.org]
[DOI]
(I p)
