Difference between revisions of "FruK"

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|style="background:#ABCDEF;" align="center"|'''Function''' || fructose utilization
 
|style="background:#ABCDEF;" align="center"|'''Function''' || fructose utilization
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU14390 fruK]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14390 fruK]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fruR]]'', ''[[fruA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fruR]]'', ''[[fruA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13312&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14390 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14390 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14390 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:fruK_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:fruK_context.gif]]

Revision as of 12:42, 13 May 2013

  • Description: fructose-1-phosphate kinase

Gene name fruK
Synonyms fruB
Essential no
Product fructose-1-phosphate kinase
Function fructose utilization
Gene expression levels in SubtiExpress: fruK
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 32 kDa, 4.885
Gene length, protein length 909 bp, 303 aa
Immediate neighbours fruR, fruA
Sequences Protein DNA Advanced_DNA
Genetic context
FruK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FruK expression.png



















Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

FruR regulon

The gene

Basic information

  • Locus tag: BSU14390

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate (according to Swiss-Prot)
  • Protein family: carbohydrate kinase pfkB family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of fructose (FruR) (according to DBTBS)
  • Regulatory mechanism:
    • FruR: transcription repression (according to DBTBS)
    • strongly induced in response to glucose starvation in M9 medium PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed