Difference between revisions of "AhrC"
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|style="background:#ABCDEF;" align="center"|'''Function''' || transcriptional regulator of arginine metabolic genes | |style="background:#ABCDEF;" align="center"|'''Function''' || transcriptional regulator of arginine metabolic genes | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24250 ahrC] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate]''' | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[recN]]'', ''[[yqxC]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[recN]]'', ''[[yqxC]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24250 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24250 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24250 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ahrC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ahrC_context.gif]] | ||
Revision as of 13:15, 13 May 2013
- Description: AhrC represses the genes for arginine biosynthesis and activates the genes for arginine catabolism.
| Gene name | ahrC |
| Synonyms | argR |
| Essential | no |
| Product | transcriptional regulator |
| Function | transcriptional regulator of arginine metabolic genes |
| Gene expression levels in SubtiExpress: ahrC | |
| Metabolic function and regulation of this protein in SubtiPathways: Ammonium/ glutamate | |
| MW, pI | 16,7 kDa, 5.52 |
| Gene length, protein length | 447 bp, 149 amino acids |
| Immediate neighbours | recN, yqxC |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, glutamate metabolism, utilization of amino acids, transcription factors and their control
This gene is a member of the following regulons
The AhrC regulon
The gene
Basic information
- Locus tag: BSU24250
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcriptional activator/ repressor of genes involved in arginine metabolism
- Protein family: argR family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): L-arginine is the co-factor required for transcription repression/ activation
- Effectors of protein activity:
- Localization: Cytoplasm
Database entries
- Structure: 2P5M (C-Terminus), 2P5K (complex with an 18bp DNA operator), 2P5L (N-terminus), 1F9N, NCBI PubMed,N-Terminus NCBI, C-Terminus NCBI, complex with an 18bp DNA operator NCBI
- UniProt: P17893
- KEGG entry: [3]
Additional information
Expression and regulation
- Sigma factor:
- Additional information:
Biological materials
- Mutant: GP729 (aphA3), available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- Antibody:
Labs working on this gene/protein
Simon Phillips, Leeds University, UK Homepage
Michel Debarbouille, Pasteur Institute, Paris, France Homepage
Your additional remarks
References
Additional publications: PubMed
