Difference between revisions of "AlkA"
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage | |style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU01800 alkA] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 8.147 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 8.147 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[glmS]]'', ''[[adaA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[glmS]]'', ''[[adaA]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU01800 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU01800 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU01800 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:alkA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:alkA_context.gif]] | ||
Revision as of 12:00, 13 May 2013
- Description: DNA-3-methyladenine glycosylase
| Gene name | alkA |
| Synonyms | |
| Essential | no |
| Product | DNA-3-methyladenine glycosylase |
| Function | adaptive response to alkylative DNA damage |
| Gene expression levels in SubtiExpress: alkA | |
| MW, pI | 35 kDa, 8.147 |
| Gene length, protein length | 909 bp, 303 aa |
| Immediate neighbours | glmS, adaA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01800
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine (according to Swiss-Prot)
- Protein family: alkylbase DNA glycosidase alkA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37878
- KEGG entry: [3]
- E.C. number: 3.2.2.21
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
F Morohoshi, K Hayashi, N Munkata
Bacillus subtilis alkA gene encoding inducible 3-methyladenine DNA glycosylase is adjacent to the ada operon.
J Bacteriol: 1993, 175(18);6010-7
[PubMed:8376346]
[WorldCat.org]
[DOI]
(P p)
