Difference between revisions of "UppS"

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|style="background:#ABCDEF;" align="center"|'''Function''' || cell wall biosynthesis  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || cell wall biosynthesis  
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU16530 uppS]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530 uppS]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frr]]'', ''[[cdsA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frr]]'', ''[[cdsA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13526&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU16530 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU16530 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU16530 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:uppS_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:uppS_context.gif]]

Revision as of 12:51, 13 May 2013

  • Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

Gene name uppS
Synonyms yluA
Essential yes PubMed
Product undecaprenyl pyrophosphate synthetase
Function cell wall biosynthesis
Gene expression levels in SubtiExpress: uppS
MW, pI 29 kDa, 5.408
Gene length, protein length 780 bp, 260 aa
Immediate neighbours frr, cdsA
Sequences Protein DNA Advanced_DNA
Genetic context
UppS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
UppS expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of lipids, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU16530

Phenotypes of a mutant

  • essential PubMed
  • the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed=== Database entries ===
  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
  • Protein family: UPP synthetase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Takashi Inaoka, Kozo Ochi
Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.
J Bacteriol: 2012, 194(20);5632-7
[PubMed:22904278] [WorldCat.org] [DOI] (I p)