Difference between revisions of "Ddl"

From SubtiWiki
Jump to: navigation, search
Line 13: Line 13:
 
|style="background:#ABCDEF;" align="center"|'''Function''' || peptidoglycan precursor biosynthesis  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || peptidoglycan precursor biosynthesis  
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU04560 ddl]
+
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04560 ddl]
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/cellwall.html Cell wall]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/cellwall.html Cell wall]'''
Line 23: Line 23:
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydbP]]'', ''[[murF]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydbP]]'', ''[[murF]]''
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12263&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU04560 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU04560 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU04560 Advanced_DNA]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ddl_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ddl_context.gif]]

Revision as of 12:11, 13 May 2013

  • Description: D-alanine-D-alanine ligase

Gene name ddl
Synonyms ddlA
Essential yes PubMed
Product D-alanine-D-alanine ligase
Function peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: ddl
Metabolic function and regulation of this protein in SubtiPathways:
Cell wall
MW, pI 38 kDa, 4.58
Gene length, protein length 1062 bp, 354 aa
Immediate neighbours ydbP, murF
Sequences Protein DNA Advanced_DNA
Genetic context
Ddl context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ddl expression.png




























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU04560

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine (according to Swiss-Prot)
  • Protein family: ATP-grasp domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2YZG (from Thermus thermophilus hb8 mutant, 40% identity, 53% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed