Upp

• Description: uracil phosphoribosyltransferase
  
  

Gene name	upp
Synonyms	ipc-35d
Essential	no
Product	uracil phosphoribosyltransferase
Function	UMP synthesis
Gene expression levels in SubtiExpress: upp
Metabolic function and regulation of this protein in SubtiPathways: Pyrimidines, Nucleotides (regulation)
MW, pI	22 kDa, 5.863
Gene length, protein length	627 bp, 209 aa
Immediate neighbours	atpI, glyA
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

The gene

Basic information

• Locus tag: BSU36890

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

• Protein family: UPRTase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2EHJ (from Escherichia coli, 52% identity, 73% similarity)

• UniProt: P39149

• KEGG entry: [3]

• E.C. number: 2.4.2.9

Expression and regulation

• Operon: upp PubMed

• Expression browser: upp PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A832 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

J Martinussen, P Glaser, P S Andersen, H H Saxild
Two genes encoding uracil phosphoribosyltransferase are present in Bacillus subtilis.
J Bacteriol: 1995, 177(1);271-4
[PubMed:7798145] [WorldCat.org] [DOI] (P p)