Difference between revisions of "CymR"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[sulfur metabolism]] | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[sulfur metabolism]] | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27520 cymR] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/CymR CymR] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/CymR CymR] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrvO]]'', ''[[yrvN]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrvO]]'', ''[[yrvN]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU27520 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU27520 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU27520 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yrzC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yrzC_context.gif]] | ||
Revision as of 13:27, 13 May 2013
- Description: pleiotropic regulator of sulfur metabolism
| Gene name | cymR |
| Synonyms | yrzC |
| Essential | no |
| Product | transcription repressor |
| Function | regulation of sulfur metabolism |
| Gene expression levels in SubtiExpress: cymR | |
| Interactions involving this protein in SubtInteract: CymR | |
| Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD, Cys, Met & Sulfate assimilation | |
| MW, pI | 11 kDa, 9.879 |
| Gene length, protein length | 333 bp, 111 aa |
| Immediate neighbours | yrvO, yrvN |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
sulfur metabolism, transcription factors and their control, regulators of core metabolism
This gene is a member of the following regulons
The CymR regulon
The gene
Basic information
- Locus tag: BSU27520
Phenotypes of a mutant
- impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat- and tellurite-induced stresses PubMed
- increased intracellular cysteine pool and hydrogen sulfide formation PubMed
- depletion of branched-chain amino acids PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Rrf2 family of transcription regulators
- Paralogous protein(s):
Genes repressed by CymR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: O34527
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Isabelle Martin-Verstraete, Institute Pasteur, Paris, France
Your additional remarks
References
The CymR regulon
Sergine Even, Pierre Burguière, Sandrine Auger, Olga Soutourina, Antoine Danchin, Isabelle Martin-Verstraete
Global control of cysteine metabolism by CymR in Bacillus subtilis.
J Bacteriol: 2006, 188(6);2184-97
[PubMed:16513748]
[WorldCat.org]
[DOI]
(P p)
Other original publications
Additional publications: PubMed
