Difference between revisions of "NusG"
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| − | + | * '''Description:''' transcription antitermination and pausing factor <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || transcription | |style="background:#ABCDEF;" align="center"|'''Function''' || transcription | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 5.252 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 5.252 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:nusG_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:nusG_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' | * '''Operon:''' | ||
| − | * | + | * '''[[Sigma factor]]:''' |
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* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
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=Biological materials = | =Biological materials = | ||
Revision as of 10:28, 7 August 2012
- Description: transcription antitermination and pausing factor
| Gene name | nusG |
| Synonyms | |
| Essential | no |
| Product | transcription antitermination and pausing factor |
| Function | transcription |
| MW, pI | 19 kDa, 5.252 |
| Gene length, protein length | 531 bp, 177 aa |
| Immediate neighbours | secE, rplK |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01010
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: KOW domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: Q06795
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Alexander V Yakhnin, Paul Babitzke
Mechanism of NusG-stimulated pausing, hairpin-dependent pause site selection and intrinsic termination at overlapping pause and termination sites in the Bacillus subtilis trp leader.
Mol Microbiol: 2010, 76(3);690-705
[PubMed:20384694]
[WorldCat.org]
[DOI]
(I p)
Alexander V Yakhnin, Helen Yakhnin, Paul Babitzke
Function of the Bacillus subtilis transcription elongation factor NusG in hairpin-dependent RNA polymerase pausing in the trp leader.
Proc Natl Acad Sci U S A: 2008, 105(42);16131-6
[PubMed:18852477]
[WorldCat.org]
[DOI]
(I p)
Geoff P Doherty, Donna H Meredith, Peter J Lewis
Subcellular partitioning of transcription factors in Bacillus subtilis.
J Bacteriol: 2006, 188(11);4101-10
[PubMed:16707701]
[WorldCat.org]
[DOI]
(P p)
C J Ingham, P A Furneaux
Mutations in the ss subunit of the Bacillus subtilis RNA polymerase that confer both rifampicin resistance and hypersensitivity to NusG.
Microbiology (Reading): 2000, 146 Pt 12;3041-3049
[PubMed:11101662]
[WorldCat.org]
[DOI]
(P p)
C J Ingham, J Dennis, P A Furneaux
Autogenous regulation of transcription termination factor Rho and the requirement for Nus factors in Bacillus subtilis.
Mol Microbiol: 1999, 31(2);651-63
[PubMed:10027981]
[WorldCat.org]
[DOI]
(P p)
