Difference between revisions of "HprT"
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− | + | * '''Description:''' hypoxanthine phosphoribosyltransferase <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || purine salvage and interconversion | |style="background:#ABCDEF;" align="center"|'''Function''' || purine salvage and interconversion | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purine_biosynthesis.html Purine synthesis], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purine_biosynthesis.html Purine synthesis], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]''' | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:hprT_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:hprT_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] | * '''Operon:''' ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] | ||
− | * | + | * '''[[Sigma factor]]:''' [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] |
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* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = |
Revision as of 10:24, 7 August 2012
- Description: hypoxanthine phosphoribosyltransferase
Gene name | hprT |
Synonyms | |
Essential | yes PubMed |
Product | hypoxanthine phosphoribosyltransferase |
Function | purine salvage and interconversion |
Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Purine synthesis, Nucleotides (regulation) | |
MW, pI | 20 kDa, 4.603 |
Gene length, protein length | 540 bp, 180 aa |
Immediate neighbours | tilS, ftsH |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00680
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
- UniProt: P37472
- KEGG entry: [2]
- E.C. number: 2.4.2.8
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421]
[WorldCat.org]
[DOI]
(P p)