CydC

• Description: ABC transporter required for expression of cytochrome bd (ATP-binding protein)
  
  

Gene name	cydC
Synonyms	yxkM
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	required for expression of cytochrome bd
Gene expression levels in SubtiExpress: cydC
Interactions involving this protein in SubtInteract: CydC
MW, pI	62 kDa, 8.511
Gene length, protein length	1701 bp, 567 aa
Immediate neighbours	cydD, cydB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, respiration, membrane proteins

This gene is a member of the following regulons

CcpA regulon, ResD regulon, Rex regulon

The gene

Basic information

• Locus tag: BSU38740

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: has both a membrane-spanning and an ATP-binding domain PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • CydD-CydC PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: P94366

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cydA-cydB-cydC-cydD PubMed

• Expression browser: cydC PubMed

• Sigma factor:

• Regulation:
  • repressed by glucose (CcpA)
  • induced under anaerobic conditions (Rex) PubMed
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression
  • Rex: transcription repression PubMed
  • ResD: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ankita Puri-Taneja, Matthew Schau, Yinghua Chen, F Marion Hulett
Regulators of the Bacillus subtilis cydABCD operon: identification of a negative regulator, CcpA, and a positive regulator, ResD.
J Bacteriol: 2007, 189(9);3348-58
[PubMed:17322317] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

Matthew Schau, Yinghua Chen, F Marion Hulett
Bacillus subtilis YdiH is a direct negative regulator of the cydABCD operon.
J Bacteriol: 2004, 186(14);4585-95
[PubMed:15231791] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

L Winstedt, K Yoshida, Y Fujita, C von Wachenfeldt
Cytochrome bd biosynthesis in Bacillus subtilis: characterization of the cydABCD operon.
J Bacteriol: 1998, 180(24);6571-80
[PubMed:9852001] [WorldCat.org] [DOI] (P p)