MutTA

• Description: error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity
  
  

Gene name	mutTA
Synonyms	ytkD, rppH
Essential	no
Product	8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase
Function	DNA repair, RNA degradation
MW, pI	18 kDa, 5.952
Gene length, protein length	474 bp, 158 aa
Immediate neighbours	ytlD, ytkC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, sporulation proteins

This gene is a member of the following regulons

SigF regulon

The gene

Basic information

• Locus tag: BSU30630

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • removal of pyrophosphate from the 5' end of mRNAs to make the RNA accessible for degradation by RNases PubMed

• Protein family: Nudix hydrolase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O35013

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mutTA PubMed

• Expression browser: mutTA PubMed

• Sigma factor: SigA PubMed, SigF PubMed

• Regulation:
  • expressed during logarithmic growth (SigA) and early during sporulation in the forespore (SigF) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Lehnik-Habrink M, Lewis RJ, Mäder U, Stülke J    
RNA degradation in Bacillus subtilis: an interplay of
essential endo- and exoribonucleases. 
Mol Microbiol.: 2012, 84(6) 1005-1017. 
PubMed:22568516