Difference between revisions of "YtpQ"
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|style="background:#ABCDEF;" align="center"| '''Product''' || unknown | |style="background:#ABCDEF;" align="center"| '''Product''' || unknown | ||
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| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || maybe involved in iron homeostasis |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 5.3 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 5.3 | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
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| − | |||
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<br/><br/> | <br/><br/> | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[ | + | {{SubtiWiki category|[[acquisition of iron]]}}, |
| + | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | {{SubtiWiki regulon|[[Spx regulon]]}} | |
=The gene= | =The gene= | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * derepression of the [[Fur]] and [[PerR]] regulons {{PubMed|21949854}} | ||
| + | * elevated oxidative protein damage upon exposure of the cells to methylglyoxal {{PubMed|21949854}} | ||
| + | * the ''[[spx]] [[ytpQ]]'' doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal {{PubMed|21949854}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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Revision as of 10:43, 1 August 2012
- Description: unknown
| Gene name | ytpQ |
| Synonyms | |
| Essential | no |
| Product | unknown |
| Function | maybe involved in iron homeostasis |
| MW, pI | 30 kDa, 5.3 |
| Gene length, protein length | 807 bp, 269 aa |
| Immediate neighbours | ytpR, ytpP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
acquisition of iron, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29830
Phenotypes of a mutant
- derepression of the Fur and PerR regulons PubMed
- elevated oxidative protein damage upon exposure of the cells to methylglyoxal PubMed
- the spx ytpQ doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0354 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O34496
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Peter Zuber, Shefali Chauhan, Praseeda Pilaka, Michiko M Nakano, Sairam Gurumoorthy, Ann A Lin, Skye M Barendt, Bui Khanh Chi, Haike Antelmann, Ulrike Mäder
Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis.
PLoS One: 2011, 6(9);e25066
[PubMed:21949854]
[WorldCat.org]
[DOI]
(I p)
