Difference between revisions of "LmrA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of lincomycin resistance | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of lincomycin resistance | ||
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| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU02680 lmrA] | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 20 kDa, 5.033 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 20 kDa, 5.033 | ||
Revision as of 14:47, 6 August 2012
| Gene name | lmrA |
| Synonyms | lin-2, yccB |
| Essential | no |
| Product | transcriptional regulator |
| Function | regulation of lincomycin resistance |
| Gene expression levels in SubtiExpress: lmrA | |
| MW, pI | 20 kDa, 5.033 |
| Gene length, protein length | 564 bp, 188 aa |
| Immediate neighbours | lmrB, ansZ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
transcription factors and their control, resistance against toxins/ antibiotics
This gene is a member of the following regulons
The LmrA regulon:
The gene
Basic information
- Locus tag: BSU02680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): QdoR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed
Database entries
- Structure:
- UniProt: O34619
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. Mol Microbiol. 2011 81(6): 1459-1473. PubMed:21815947
Kazutake Hirooka, Satoshi Kunikane, Hiroshi Matsuoka, Ken-Ichi Yoshida, Kanako Kumamoto, Shigeo Tojo, Yasutaro Fujita
Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids.
J Bacteriol: 2007, 189(14);5170-82
[PubMed:17483215]
[WorldCat.org]
[DOI]
(P p)
Ken-Ichi Yoshida, Yo-Hei Ohki, Makiko Murata, Masaki Kinehara, Hiroshi Matsuoka, Takenori Satomura, Reiko Ohki, Miyuki Kumano, Kunio Yamane, Yasutaro Fujita
Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons: identification of its binding site and functional analysis of lmrB and yxaGH.
J Bacteriol: 2004, 186(17);5640-8
[PubMed:15317768]
[WorldCat.org]
[DOI]
(P p)
Miyuki Kumano, Masaya Fujita, Kouji Nakamura, Makiko Murata, Reiko Ohki, Kunio Yamane
Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.
Antimicrob Agents Chemother: 2003, 47(1);432-5
[PubMed:12499232]
[WorldCat.org]
[DOI]
(P p)
