Difference between revisions of "UvrA"

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Revision as of 10:12, 23 April 2012

  • Description: excinuclease ABC (subunit A)

Gene name uvrA
Synonyms
Essential no
Product excinuclease ABC (subunit A)
Function DNA repair after UV damage
Interactions involving this protein in SubtInteract: UvrA
MW, pI 105 kDa, 5.843
Gene length, protein length 2871 bp, 957 aa
Immediate neighbours yvzB, uvrB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
UvrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
UvrA expression.png
























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

  • Locus tag: BSU35160

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: UvrA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2R6F (Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • mutant: GP1175 (del uvrAB::ermC) (available in the Stülke lab)
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications

Bradley T Smith, Alan D Grossman, Graham C Walker
Localization of UvrA and effect of DNA damage on the chromosome of Bacillus subtilis.
J Bacteriol: 2002, 184(2);488-93
[PubMed:11751826] [WorldCat.org] [DOI] (P p)

C M Lovett, K C Cho, T M O'Gara
Purification of an SOS repressor from Bacillus subtilis.
J Bacteriol: 1993, 175(21);6842-9
[PubMed:8226626] [WorldCat.org] [DOI] (P p)