Difference between revisions of "Tig"

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|colspan="2" | '''Genetic context''' <br/> [[Image:tig_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:tig_context.gif]]
 
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=tig_2886315_2887589_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:tig_expression.png|500px]]
 
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Revision as of 10:20, 20 April 2012

  • Description: trigger factor (prolyl isomerase)

Gene name tig
Synonyms yzzH
Essential no
Product trigger factor (prolyl isomerase)
Function protein folding
MW, pI 47 kDa, 4.224
Gene length, protein length 1272 bp, 424 aa
Immediate neighbours clpX, ysoA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Tig context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Tig expression.png
























Categories containing this gene/protein

chaperones/ protein folding, phosphoproteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU28230

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Tig subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2VRH (the E. coli trigger factor) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Sigma factor:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:
    • subject to Clp-dependent proteolysis upon glucose starvation PubMed
    • The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications