Difference between revisions of "SipW"

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* '''Description:''' signal peptidase I, processes [[TasA]] and [[TapA]], required for [[biofilm formation]] <br/><br/>
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* '''Description:''' bifunctional signal peptidase I that controls surface-adhered [[biofilm formation]] and processes [[TasA]] and [[TapA]]<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:''' Cleavage of hydrophobic, N-terminal signal or leader sequences from [[TasA]] and [[TapA]]  
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* '''Catalyzed reaction/ biological activity:'''
 +
** important for [[biofilm formation]] on a solid surface, but not required at an air-liquid interface {{PubMed|22328672}}
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** Cleavage of hydrophobic, N-terminal signal or leader sequences from [[TasA]] and [[TapA]]  
  
 
* '''Protein family:''' peptidase S26B family (according to Swiss-Prot)
 
* '''Protein family:''' peptidase S26B family (according to Swiss-Prot)
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=Labs working on this gene/protein=
 
=Labs working on this gene/protein=
 +
* [[Beth Lazazzera]], Los Angeles, USA
  
 
=Your additional remarks=
 
=Your additional remarks=
 
 
=References=
 
=References=
 
==Reviews==
 
==Reviews==
<pubmed> 21488983 </pubmed>
+
<pubmed> 21488983 22328672</pubmed>
 
==Original publications==
 
==Original publications==
 
  <big>''Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J''  </big>
 
  <big>''Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J''  </big>

Revision as of 19:14, 18 February 2012

Gene name sipW
Synonyms yqhE
Essential no
Product signal peptidase I
Function biofilm formation
Regulation of this protein in SubtiPathways:
Biofilm, Protein secretion
MW, pI 20 kDa, 5.494
Gene length, protein length 570 bp, 190 aa
Immediate neighbours tasA, tapA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SipW context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

protein secretion, biofilm formation, membrane proteins

This gene is a member of the following regulons

AbrB regulon, SinR regulon

The gene

Basic information

  • Locus tag: BSU24630

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • important for biofilm formation on a solid surface, but not required at an air-liquid interface PubMed
    • Cleavage of hydrophobic, N-terminal signal or leader sequences from TasA and TapA
  • Protein family: peptidase S26B family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947
Diethmaier C, Pietack N, Gunka K, Wrede C, Lehnik-Habrink M, Herzberg C, Hübner S, Stülke J  
A Novel Factor Controlling Bistability in Bacillus subtilis: The YmdB Protein Affects
Flagellin Expression and Biofilm Formation. 
J Bacteriol.: 2011, 193(21):5997-6007. 
PubMed:21856853