Difference between revisions of "Ddl"
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| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ddl_508248_509312_1 ddl] {{PubMed|22383849}} |
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| + | * '''Sigma factor:''' [[SigM]] {{PubMed|18179421}} | ||
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=Biological materials = | =Biological materials = | ||
Revision as of 14:42, 12 April 2012
- Description: D-alanine-D-alanine ligase
| Gene name | ddl |
| Synonyms | ddlA |
| Essential | yes PubMed |
| Product | D-alanine-D-alanine ligase |
| Function | peptidoglycan precursor biosynthesis |
| Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
| MW, pI | 38 kDa, 4.58 |
| Gene length, protein length | 1062 bp, 354 aa |
| Immediate neighbours | ydbP, murF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU04560
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine (according to Swiss-Prot)
- Protein family: ATP-grasp domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 2YZG (from Thermus thermophilus hb8 mutant, 40% identity, 53% similarity)
- UniProt: P96612
- KEGG entry: [2]
- E.C. number: 6.3.2.4
Additional information
Expression and regulation
- Operon:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421]
[WorldCat.org]
[DOI]
(P p)
