PutR

• Description: transcriptional activator of the proline utilization operon putB-putC-putP
  
  

Gene name	putR
Synonyms	ycgP, prcR
Essential	no
Product	transcriptional activator
Function	regulation of proline utilization
MW, pI	47 kDa, 5.37
Gene length, protein length	1233 bp, 411 aa
Immediate neighbours	putP, ycgQ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, utilization of amino acids

The PutR regulon:

• putB-putC-putP

The gene

Basic information

• Locus tag: BSU03230

Phenotypes of a mutant

• no growth with proline as single source of carbon or nitrogen PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activation of the proline utilization operon putB-putC-putP in the presence of proline PubMed

• Protein family: cdaR family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): proline acts as co-activator PubMed

• Effectors of protein activity: proline activates PutR PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94393

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: putR PubMed

• Expression browser: putR PubMed

• Sigma factor: SigA PubMed

• Regulation: constitutively expressed PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Boris R Belitsky
Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon.
J Mol Biol: 2011, 413(2);321-36
[PubMed:21840319] [WorldCat.org] [DOI] (I p)