Difference between revisions of "NprE"

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* '''Operon:''' ''nprE'' (according to [http://dbtbs.hgc.jp/COG/prom/nprE.html DBTBS])
 
* '''Operon:''' ''nprE'' (according to [http://dbtbs.hgc.jp/COG/prom/nprE.html DBTBS])
  
* '''[[Sigma factor]]:'''  
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=nprE_1540036_1541601_-1 nprE] {{PubMed|22383849}}
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* '''Sigma factor:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  

Revision as of 08:12, 13 April 2012

  • Description: extracellular neutral protease B

Gene name nprE
Synonyms
Essential no
Product extracellular neutral protease B
Function degradation of proteins
MW, pI 56 kDa, 7.481
Gene length, protein length 1563 bp, 521 aa
Immediate neighbours yktD, ylaA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NprE context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

utilization of nitrogen sources other than amino acids

This gene is a member of the following regulons

AbrB regulon, ScoC regulon

The gene

Basic information

  • Locus tag: BSU14700

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Similar, but not identical, to that of thermolysin (according to Swiss-Prot)
  • Protein family: peptidase M4 family (according to Swiss-Prot)
  • Paralogous protein(s): NprB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1NPC (of Bacillus cereus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: nprE (according to DBTBS)
  • Sigma factor:
  • Regulation:
    • repressed during exponential growth (ScoC) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications

Additional publications: PubMed

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)

P T Kallio, J E Fagelson, J A Hoch, M A Strauch
The transition state regulator Hpr of Bacillus subtilis is a DNA-binding protein.
J Biol Chem: 1991, 266(20);13411-7
[PubMed:1906467] [WorldCat.org] (P p)