ArsB

• Description: extrusion of arsenite
  
  

Gene name	arsB
Synonyms	yqcL
Essential	no
Product	arsenite exporter
Function	detoxification of arsenate and arsenite
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	38 kDa, 9.773
Gene length, protein length	1038 bp, 346 aa
Immediate neighbours	arsC, yqcK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, resistance against toxic metals, Skin element

This gene is a member of the following regulons

ArsR regulon, SigF regulon

The gene

Basic information

• Locus tag: BSU25790

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ACR3 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45946

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: arsR-yqcK-arsB-arsC PubMed

• Expression browser: arsB PubMed

• Sigma factor: SigA PubMed, SigF PubMed

• Regulation:
  • expressed early during sporulation in the forespore (SigF) PubMed
  • expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) (ArsR) PubMed

• Regulatory mechanism:
  • ArsR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J Bacteriol: 1998, 180(7);1655-61
[PubMed:9537360] [WorldCat.org] [DOI] (P p)