Difference between revisions of "HypO"
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|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''hypO'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yfkO'' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| Line 46: | Line 46: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | hypO ohrA mutant more sensitive to NaOCl stress than ohrA single mutant | + | * a ''[[hypO]] [[ohrA]]'' mutant is more sensitive to NaOCl stress than ''[[ohrA]]'' single mutant {{PubMed|22238377}} |
=== Database entries === | === Database entries === | ||
| Line 79: | Line 79: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
| Line 97: | Line 97: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' '' | + | * '''Operon:''' ''hypO'' (according to [http://dbtbs.hgc.jp/COG/prom/yfkO.html DBTBS]) |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' induced under disulfide stress conditions (diamide, NaOCl) ([[HypR]]) {{PubMed|22238377}} | + | * '''Regulation:''' |
| + | ** induced under disulfide stress conditions (diamide, NaOCl) ([[HypR]]) {{PubMed|22238377}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 127: | Line 128: | ||
=References= | =References= | ||
| − | <pubmed>20727918 | + | '''Additional publications:''' {{PubMed|22238377}} |
| + | <pubmed>20727918</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:41, 16 January 2012
- Description: NAD(P)H-flavin nitroreductase
| Gene name | hypO |
| Synonyms | yfkO |
| Essential | no |
| Product | NAD(P)H-flavin nitroreductase |
| Function | probably involved in NaOCl and diamide detoxification |
| MW, pI | 25 kDa, 5.667 |
| Gene length, protein length | 663 bp, 221 aa |
| Immediate neighbours | treR, yfkN |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
electron transport/ other, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU07830
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: nitroreductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O34475
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: hypO (according to DBTBS)
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
G A Prosser, A V Patterson, D F Ackerley
uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.
J Biotechnol: 2010, 150(1);190-4
[PubMed:20727918]
[WorldCat.org]
[DOI]
(I p)
