SecE

• Description: preprotein translocase subunit
  
  

Gene name	secE
Synonyms
Essential	yes PubMed
Product	preprotein translocase subunit
Function	protein secretion
Interactions involving this protein in SubtInteract: SecE
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	6 kDa, 10.47
Gene length, protein length	177 bp, 59 aa
Immediate neighbours	rpmGB, nusG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

protein secretion, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU01000

Expression

Phenotypes of a mutant

essential PubMed PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secE/SEC61-gamma family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: transmembrane protein with a single TM domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (SecY-SecE-SecG)2-SecA2 PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 3DL8 (structure of the (SecY-SecE-SecG)-SecA complex) PubMed

• UniProt: Q06799

• KEGG entry: [2]

• E.C. number:

Additional information

B. subtilis secE complements the secretion phenotype of a cold sensitive E. coli secE mutant.

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

S M Jeong, H Yoshikawa, H Takahashi
Isolation and characterization of the secE homologue gene of Bacillus subtilis.
Mol Microbiol: 1993, 10(1);133-42
[PubMed:7968510] [WorldCat.org] [DOI] (P p)