Difference between revisions of "DnaN"
| Line 88: | Line 88: | ||
** [[PolY1]]-[[PolA]]-[[DnaN]] {{PubMed|16045613}} | ** [[PolY1]]-[[PolA]]-[[DnaN]] {{PubMed|16045613}} | ||
** [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}} | ** [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}} | ||
| − | ** DnaN forms dimers {{PubMed|16045613}} | + | ** [[MutS]]-[[DnaN]] {{PubMed|20453097}} |
| + | ** [[DnaE]]-[[DnaN]] {{PubMed|21958350}} | ||
| + | ** [[DnaN]] forms dimers {{PubMed|16045613}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
** nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | ** nucleoid (mid-cell spot) [http://www.ncbi.nlm.nih.gov/sites/entrez/9822387 PubMed] [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed] | ||
** forms large assemblies on DNA, called "clamp zones" {{PubMed|21419346}} | ** forms large assemblies on DNA, called "clamp zones" {{PubMed|21419346}} | ||
| + | ** forms foci {{PubMed|21958350}} | ||
=== Database entries === | === Database entries === | ||
| Line 143: | Line 146: | ||
<pubmed> 20157337 </pubmed> | <pubmed> 20157337 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | '''Additional publications:''' {{PubMed|21050827,21419346}} | + | '''Additional publications:''' {{PubMed|21050827,21419346,21958350}} |
| − | <pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 19081080 11395445 20122408 20451384 15469515 16045613 21895792 </pubmed> | + | <pubmed>16942601 9822387 14651647,2987848 2168872 14651647 12060778 16461910, 16479537 19737352 19081080 11395445 20122408 20451384 15469515 16045613 21895792 20453097 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:07, 24 October 2011
- Description: DNA polymerase III (beta subunit), beta clamp, part of the replisome, also involved in DNA mismatch repair
| Gene name | dnaN |
| Synonyms | dnaG, dnaK |
| Essential | yes PubMed |
| Product | DNA polymerase III (beta subunit), beta clamp |
| Function | DNA replication, DNA repair |
| Interactions involving this protein in SubtInteract: DnaN | |
| MW, pI | 41 kDa, 4.718 |
| Gene length, protein length | 1134 bp, 378 aa |
| Immediate neighbours | dnaA, yaaA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00020
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- DnaA-YabA-DnaN PubMed
- part of the replisome: PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed
- PolY1-DnaN, PolY2-DnaN (required for untargeted mutagenesis) PubMed
- PolY1-PolA-DnaN PubMed
- MutL (C-terminal domain)-DnaN PubMed
- MutS-DnaN PubMed
- DnaE-DnaN PubMed
- DnaN forms dimers PubMed
Database entries
- Structure:
- UniProt: P05649
- KEGG entry: [3]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Philippe Noirot, Jouy-en-Josas, France homepage
Your additional remarks
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
Additional publications: PubMed
