Difference between revisions of "FloT"
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| − | * '''Description:''' similar to flottilin 1, orchestration of physiological processes in lipid microdomains <br/><br/> | + | * '''Description:''' similar to flottilin 1, orchestration of physiological processes in lipid microdomains, involved in the control of membrane fluidity, confers resistance to cefuroxime <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || involved in the control of membrane fluidity |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/FloT FloT] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 55 kDa, 5.135 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 55 kDa, 5.135 | ||
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=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** [[SigW]]-dependent expression of ''[[fabF]]'' and the ''[[yuaF]]-[[floT]]-[[yuaI]]'' operon result in reduced membrane fluidity {{PubMed|21542858,22178969}} | ||
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[YuaF]]-[[FloT]] (suspected based on conserved operon organisation and common function) {{PubMed|18696230,22178969}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
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=References= | =References= | ||
| − | + | '''Additional publications:''' {{PubMed|22178969}} | |
<pubmed>9987136,, 12107147, 18763711, 19383680 20713508 </pubmed> | <pubmed>9987136,, 12107147, 18763711, 19383680 20713508 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:01, 1 January 2012
- Description: similar to flottilin 1, orchestration of physiological processes in lipid microdomains, involved in the control of membrane fluidity, confers resistance to cefuroxime
| Gene name | floT |
| Synonyms | yuaG, yuaH |
| Essential | no |
| Product | |
| Function | involved in the control of membrane fluidity |
| Interactions involving this protein in SubtInteract: FloT | |
| MW, pI | 55 kDa, 5.135 |
| Gene length, protein length | 1527 bp, 509 aa |
| Immediate neighbours | yuaI, yuaF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
biofilm formation, membrane dynamics, membrane proteins sporulation/ other, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31010
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O32076
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
