YtrA

• Description: transcriptional repressor, GntR family, control of cell envelope stress responses in response to ramoplanin
  
  

Gene name	ytrA
Synonyms
Essential	no
Product	transcriptional repressor (GntR family)
Function	control of cell envelope stress responses
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	14 kDa, 8.094
Gene length, protein length	390 bp, 130 aa
Immediate neighbours	ytrB, ytrG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, cold stress proteins

This gene is a member of the following regulons

YtrA regulon

The gene

Basic information

• Locus tag: BSU30460

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3NEU (similar protein from Listeria innocua, 41% identity)

• UniProt: O34712

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytrG-ytrA-ytrB-ytrC-ytrD-ytrE-ytrF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by ramoplanin (YtrA) PubMed
  • expressed early in the stationary phase PubMed
  • induced by cold shock (5-fold) PubMed

• Regulatory mechanism:
  • YtrA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed