RsbV

• Description: anti-anti-SigB, antagonist of RsbW
  
  

Gene name	rsbV
Synonyms
Essential	no
Product	anti-anti-SigB
Function	control of SigB activity
Interactions involving this protein in SubtInteract: RsbV
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	11 kDa, 4.698
Gene length, protein length	327 bp, 109 aa
Immediate neighbours	rsbU, rsbW
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

sigma factors and their control, general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

CcpA regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU04710

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: STAS domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-52 AND Ser-56 by RsbW PubMed, PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbU-RsbV PubMed
  • RsbP-RsbV PubMed
  • RsbV-SpoIIAB PubMed
  • RsbV-RsbWPubMed

• Localization:

Database entries

• Structure: 1VC1 (homolog from Thermotoga maritima)

• UniProt: P17903

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX PubMed
  • rsbV-rsbW-sigB-rsbX PubMed

• Sigma factor:
  • rsbR: SigA PubMed
  • rsbV: SigB PubMed

• Regulation:
  • rsbV: induced by stress (SigB) PubMed
• rsbV: repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Bill Haldenwang, San Antonio, USA
• Chet Price, Davis, USA homepage

References

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936