Difference between revisions of "WalK"

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(Extended information on the protein)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[WalK]]-[[WalR]], [[WalK]]-[[YycH]] {{PubMed|21219466}}, [[WalK]]-[[YycI]] {{PubMed|21219466}}, [[WalK]]-[[DivIB]] {{PubMed|21219466}}, [[WalK]]-[[FtsL]] {{PubMed|21219466}}, [[WalK]]-[[PbpB]] {{PubMed|21219466}}
+
* '''[[SubtInteract|Interactions]]:'''
 +
** [[WalK]]-[[WalR]], [[WalK]]-[[YycH]] {{PubMed|21219466}}, [[WalK]]-[[YycI]] {{PubMed|21219466}}, [[WalK]]-[[DivIB]] {{PubMed|21219466}}, [[WalK]]-[[FtsL]] {{PubMed|21219466}}, [[WalK]]-[[PbpB]] {{PubMed|21219466}}
  
* '''Localization:''' cell membrane {{PubMed|21219466}}, part of the division septum in growing cells, interacts with the [[divisome]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18573169 PubMed]
+
* '''[[Localization]]:'''  
 +
** cell membrane {{PubMed|21219466}}
 +
** part of the division septum in growing cells, interacts with the [[divisome]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18573169 PubMed]
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 12:30, 10 August 2011

  • Description: two-component sensor kinase, controls cell wall metabolism, co-ordinates cell wall remodelling with cell division by controlling the transcription of genes for autolysins and their inhibitors

Gene name walK
Synonyms yycG
Essential yes PubMed
Product two-component sensor kinase (OmpR family)
Function control of cell wall metabolism
Interactions involving this protein in SubtInteract: WalK
MW, pI 69 kDa, 4.775
Gene length, protein length 1833 bp, 611 aa
Immediate neighbours yycH, walR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YycG context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall/ other, protein modification, transcription factors and their control, essential genes, membrane proteins, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU40400

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of WalR
  • Protein family: two-component sensor kinase of the OmpR family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Sarah Dubrac, Paola Bisicchia, Kevin M Devine, Tarek Msadek
A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway.
Mol Microbiol: 2008, 70(6);1307-22
[PubMed:19019149] [WorldCat.org] [DOI] (I p)

Sarah Dubrac, Tarek Msadek
Tearing down the wall: peptidoglycan metabolism and the WalK/WalR (YycG/YycF) essential two-component system.
Adv Exp Med Biol: 2008, 631;214-28
[PubMed:18792692] [WorldCat.org] [DOI] (P p)

Malcolm E Winkler, James A Hoch
Essentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria.
J Bacteriol: 2008, 190(8);2645-8
[PubMed:18245295] [WorldCat.org] [DOI] (I p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)


Original Publications