Difference between revisions of "L-box"
| Line 7: | Line 7: | ||
==References== | ==References== | ||
<pubmed> 14523230, 17143270 ,14597663 14627808 21169337 </pubmed> | <pubmed> 14523230, 17143270 ,14597663 14627808 21169337 </pubmed> | ||
| + | =See also:= | ||
| + | * [[RNA switch]] | ||
| + | |||
| + | =Back to [[regulons]]= | ||
Revision as of 20:34, 9 April 2011
The L-box is a riboswitch that binds lysine and controls gene expression by a termination/ antitermination mechanism. Upon binding of lysine, the L-box adopts a terminator structure thtus preventing expression of lysC. In the absence of lysine, the L-box has an antiterminator structure that allows lysC expression and thus lysine biosynthesis.
Gene controlled by a L-box mechanism
References
Simon Blouin, Raja Chinnappan, Daniel A Lafontaine
Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation.
Nucleic Acids Res: 2011, 39(8);3373-87
[PubMed:21169337]
[WorldCat.org]
[DOI]
(I p)
Kenneth F Blount, Joy Xin Wang, Jinsoo Lim, Narasimhan Sudarsan, Ronald R Breaker
Antibacterial lysine analogs that target lysine riboswitches.
Nat Chem Biol: 2007, 3(1);44-9
[PubMed:17143270]
[WorldCat.org]
[DOI]
(P p)
Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
Nucleic Acids Res: 2003, 31(23);6748-57
[PubMed:14627808]
[WorldCat.org]
[DOI]
(I p)
Narasimhan Sudarsan, J Kenneth Wickiser, Shingo Nakamura, Margaret S Ebert, Ronald R Breaker
An mRNA structure in bacteria that controls gene expression by binding lysine.
Genes Dev: 2003, 17(21);2688-97
[PubMed:14597663]
[WorldCat.org]
[DOI]
(P p)
Frank J Grundy, Susan C Lehman, Tina M Henkin
The L box regulon: lysine sensing by leader RNAs of bacterial lysine biosynthesis genes.
Proc Natl Acad Sci U S A: 2003, 100(21);12057-62
[PubMed:14523230]
[WorldCat.org]
[DOI]
(P p)
