MntA

• Description: manganese ABC transporter (binding protein)
  
  

Gene name	mntA
Synonyms	ytgA
Essential	yes PubMed
Product	manganese ABC transporter (binding protein)
Function	manganese uptake
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	33 kDa, 6.162
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	mntB, menC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)

This gene is a member of the following regulons

MntR regulon

The gene

Basic information

• Locus tag: BSU30770

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)

• Paralogous protein(s): YcdH

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MntB-(MntC-MntD)-MntA PubMed

• Localization: cell membrane (according to Swiss-Prot), extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: O34385

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntA-mntB-mntC-mntD PubMed

• Sigma factor:

• Regulation:
  • repressed at high Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism:
  • MntR: transcription repression PubMed

• Additional information:
  • A ncRNA is predicted between mntA and menC PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage