Difference between revisions of "LuxS"
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| − | * '''Description:''' S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and | + | * '''Description:''' S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and [[biofilm formation]] <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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=References= | =References= | ||
| − | <pubmed>11553770, 19258532 9387221 </pubmed> | + | <pubmed>11553770, 19258532 9387221 16740951 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:55, 26 December 2010
- Description: S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and biofilm formation
| Gene name | luxS |
| Synonyms | ytjB |
| Essential | no |
| Product | S-ribosylhomocysteine lyase |
| Function | methionine salvage |
| Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation | |
| MW, pI | 17 kDa, 5.168 |
| Gene length, protein length | 471 bp, 157 aa |
| Immediate neighbours | ytkA, ytjA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, biofilm formation
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU30670
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot)
- Protein family: luxS family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: subject to feedback inhibition PubMed
- Interactions:
- Localization:
Database entries
- UniProt: O34667
- KEGG entry: [3]
- E.C. number: 4.4.1.21
Additional information
Expression and regulation
- Operon: luxS PubMed
- Regulation:
- Regulatory mechanism:
- Additional information: subject to feedback inhibition PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532]
[WorldCat.org]
[DOI]
(I p)
Esteban Lombardía, Adrián J Rovetto, Ana L Arabolaza, Roberto R Grau
A LuxS-dependent cell-to-cell language regulates social behavior and development in Bacillus subtilis.
J Bacteriol: 2006, 188(12);4442-52
[PubMed:16740951]
[WorldCat.org]
[DOI]
(P p)
M T Hilgers, M L Ludwig
Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site.
Proc Natl Acad Sci U S A: 2001, 98(20);11169-74
[PubMed:11553770]
[WorldCat.org]
[DOI]
(P p)
Alia Lapidus, Nathalie Galleron, Alexei Sorokin, S Dusko Ehrlich
Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.
Microbiology (Reading): 1997, 143 ( Pt 11);3431-3441
[PubMed:9387221]
[WorldCat.org]
[DOI]
(P p)
