Difference between revisions of "AbrB"

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{{SubtiWiki regulon|[[AbrB regulon]]}},
 
{{SubtiWiki regulon|[[AbrB regulon]]}},
 
{{SubtiWiki regulon|[[Spo0A regulon]]}}
 
{{SubtiWiki regulon|[[Spo0A regulon]]}}
 
+
=The [[AbrB regulon]]=
 
=The gene=
 
=The gene=
  
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Paralogous protein(s):''' [[Abh]], [[SpoVT]] (only N-terminal domain)
 
* '''Paralogous protein(s):''' [[Abh]], [[SpoVT]] (only N-terminal domain)
 
=== Genes/ operons controlled by AbrB ===
 
 
* '''Activated by AbrB:''' ''[[citB]]'', ''[[hpr]]'', ''[[rbsR]]-[[rbsK]]-[[rbsD]]-[[rbsA]]-[[rbsC]]-[[rbsB]]''
 
 
* ''' Repressed by AbrB:''' ''[[abrB]], [[aprE]], [[comK]], [[ftsA]]-[[ftsZ]], [[kinB]], [[pbpE]], [[sigH]], [[spoVG]], [[spo0E]], [[tycA]], [[sbo]]-[[alb]], [[yqxM]]-[[sipW]]-[[tasA]], [[sdpA]]-[[sdpB]]-[[sdpC]], [[sunA]], [[skfA operon]], [[sinI]]-[[sinR]], [[sigW]], [[yuaB]]''
 
  
 
=== Extended information on the protein ===
 
=== Extended information on the protein ===
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==Reviews==
 
==Reviews==
 
<pubmed>11964117 19995980 11931565 </pubmed>
 
<pubmed>11964117 19995980 11931565 </pubmed>
 +
==The [[AbrB regulon]]==
 +
<pubmed> 20817675,18840696,</pubmed>
 +
==Other original publications==
 
==Original Publications==
 
==Original Publications==
<pubmed> 19581368 ,3145384,2437099,8878039,2504584, 11377867,1850083,2106683,12586407, 12076816,17660417, 2554317,18430133,7768874, 2507867, 1766371, 15687200,1908787,18840696,2106683,15687200, 2504584,18840696 3145384 8821944 8576231 11101897 11395475 11583849 11751836 12123659 12076816 12591885 15610005 16223496 16159768 16702211 17660417 17720793 7592460, 19465659  20509597 20817675</pubmed>
+
<pubmed> 19581368 ,3145384,2437099,8878039,2504584, 11377867,1850083,2106683,12586407, 12076816,17660417, 2554317,18430133,7768874, 2507867, 1766371, 15687200,1908787,2106683,15687200, 2504584,3145384 8821944 8576231 11101897 11395475 11583849 11751836 12123659 12076816 12591885 15610005 16223496 16159768 16702211 17660417 17720793 7592460, 19465659  20509597 </pubmed>
 
Other publications: {{PubMed|19202088,18326573}}
 
Other publications: {{PubMed|19202088,18326573}}
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 08:06, 11 December 2010

  • Description: transcriptional regulator of transition state genes

Gene name abrB
Synonyms cpsX, tolB
Essential no
Product transcriptional regulator
Function regulation of gene expression during the transition
from growth to stationary phase
Metabolic function and regulation of this protein in SubtiPathways:
Biofilm, His, Asp, Asn, Phosphorelay, Ammonium/ glutamate,
Central C-metabolism, Sugar catabolism
MW, pI 10 kDa, 6.57
Gene length, protein length 282 bp, 94 aa
Immediate neighbours yabC, metS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AbrB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

transition state regulators

This gene is a member of the following regulons

AbrB regulon, Spo0A regulon

The AbrB regulon

The gene

Basic information

  • Locus tag: BSU00370

Phenotypes of a mutant

No swarming motility on B medium. PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): Abh, SpoVT (only N-terminal domain)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on Ser-86 PubMed
  • Cofactor(s):
  • Effectors of protein activity: interaction with AbbA results in inactivation of AbrB PubMed
  • Localization:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: expressed at the onset of stationary phase PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed during logrithmic growth (AbrB) PubMed
  • Additional information:

Biological materials

  • Mutant: TT731 (aphA3)
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
  • Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

Mark Strauch, Baltimore, USA homepage

Your additional remarks

References

Reviews

The AbrB regulon

Other original publications

Original Publications

Other publications: PubMed