SdpI

• Description: immunity protein, protection against SdpC
  
  

Gene name	sdpI
Synonyms	yvaZ
Essential	no
Product	immunity protein
Function	protection against SdpC
MW, pI	23 kDa, 9.61
Gene length, protein length	621 bp, 207 aa
Immediate neighbours	sdpC, sdpR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33780

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YfhL, YbgB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: in the presence of extracellular SdpC, SdpI binds and sequesters SdpR , this results in induction of the sdpR-sdpI operon PubMed

• Interactions: SdpI-SdpR PubMed

• Localization: membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32241

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpR-sdpI PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during logrithmic growth (AbrB) PubMed
  • induced by extracellular SdpC (SdpR) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed
  • SdpR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Original Publications

Tatyana Leonidovna Povolotsky, Ekaterina Orlova, Dorjee G Tamang, Milton H Saier
Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins.
J Membr Biol: 2010, 235(3);145-62
[PubMed:20563570] [WorldCat.org] [DOI] (I p)

Craig D Ellermeier, Errett C Hobbs, Jose E Gonzalez-Pastor, Richard Losick
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.
Cell: 2006, 124(3);549-59
[PubMed:16469701] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)