TcyK

• Description: cystine ABC transporter (binding protein)
  
  

Gene name	tcyK
Synonyms	ytmK
Essential	no
Product	cystine ABC transporter (binding protein)
Function	cystine uptake
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	30 kDa, 9.009
Gene length, protein length	810 bp, 270 aa
Immediate neighbours	tcyL, tcyJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29370

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 3 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: TcyN-(TcyL-TcyM)-(TcyJ-TcyK) PubMed

• Localization: attached to the membrane via TcyL-TcyM PubMed

Database entries

• Structure: 2O1M

• UniProt: O34852

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytmI-tcyJ-tcyK-tcyL-tcyM-tcyN-ytmO-ytnI-ytnJ-ribR-ytnL-ytnM PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • YtlI: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed