Ugd

• Description: UDP-glucose dehydrogenase
  
  

Gene name	ugd
Synonyms	ywqF
Essential	no
Product	UDP-glucose dehydrogenase
Function	unknown
MW, pI	47 kDa, 5.03
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	ywqG, ptpZ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU36230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH (according to Swiss-Prot)

• Protein family: UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): TuaD, YtcA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Tyr-70 by PtkA PubMed, dephosphorylated by PtpZ PubMed

• Cofactor(s):

• Effectors of protein activity: phosphorylation by PtkA stimulates activity of Ugd PubMed

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96718

• KEGG entry: [3]

• E.C. number: 1.1.1.22

Expression and regulation

• Operon: tkmA-ptkA-ptpZ-ugd PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • DegU-P: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: