FtsA

• Description: cell-division protein, membrane anchor for FtsZ
  
  

Gene name	ftsA
Synonyms	spoIIN
Essential	yes PubMed
Product	cell-division protein
Function	formation of Z-ring
MW, pI	47 kDa, 5.094
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	sbp, ftsZ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15280

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

cell division, essential genes, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsA/mreB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: FtsZ-FtsA

• Localization:
  • septal at the cell membrane PubMed
  • septal localization depends on the proton motive force PubMed

Database entries

• Structure:

• UniProt: P28264

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsA-ftsZ PubMed

• Sigma factor: SigA PubMed, SigH PubMed

• Regulation: activated by WalR PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)