Difference between revisions of "YjbH"
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| − | * '''Description:''' adaptor protein for [[ClpX]]-[[ClpP]]-catalyzed [[Spx]] degradation <br/><br/> | + | * '''Description:''' adaptor protein for [[ClpX]]-[[ClpP]]-catalyzed [[Spx]] degradation, confers resistance against nitrosylating agents <br/><br/> |
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* '''Interactions:''' YjbH-[[Spx]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed] | * '''Interactions:''' YjbH-[[Spx]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed] | ||
| − | * '''Localization:''' | + | * '''Localization:''' cytosolic protein |
=== Database entries === | === Database entries === | ||
Revision as of 20:27, 5 June 2010
- Description: adaptor protein for ClpX-ClpP-catalyzed Spx degradation, confers resistance against nitrosylating agents
| Gene name | yjbH |
| Synonyms | |
| Essential | no |
| Product | adaptor protein |
| Function | stimulation of Spx degradation |
| MW, pI | 31 kDa, 5.206 |
| Gene length, protein length | 825 bp, 275 aa |
| Immediate neighbours | pepF, yjbI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU11550
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: adaptor protein for ClpX-ClpP-catalyzed Spx degradation PubMed
- Protein family: UPF0413 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):contains Zn atoms (coordinated by the N-terminal His-rich region) PubMed
- Effectors of protein activity: Zn atom is released upon treatment with strong oxidants PubMed
- Localization: cytosolic protein
Database entries
- Structure:
- UniProt: O31606
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Peter Zuber, Oregon Health and Science University, USA Homepage
Claes von Wachenfeldt, Lund University, Sweden Homepage
Your additional remarks
References
Reviews
Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260]
[WorldCat.org]
[DOI]
(I p)
Original Publications
Saurabh K Garg, Sushma Kommineni, Luke Henslee, Ying Zhang, Peter Zuber
The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx.
J Bacteriol: 2009, 191(4);1268-77
[PubMed:19074380]
[WorldCat.org]
[DOI]
(I p)
Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis.
Mol Microbiol: 2007, 66(3);669-84
[PubMed:17908206]
[WorldCat.org]
[DOI]
(P p)
Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416]
[WorldCat.org]
[DOI]
(P p)
