Difference between revisions of "FapR"
| Line 70: | Line 70: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' malonyl-CoA | + | * '''Effectors of protein activity:''' malonyl-CoA and malonyl-[[AcpA|ACP]] act as the molecular inducer of the FapR regulon {{PubMed|20201588}} |
| − | * '''Interactions:''' | + | * '''Interactions:''' malonyl-[[AcpA|ACP]]-[[FapR]] {{PubMed|20201588}} |
* '''Localization:''' | * '''Localization:''' | ||
| Line 95: | Line 95: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** | + | ** repressed in the absence of malonyl-CoA or malonyl-[[AcpA|ACP]] ([[FapR]]) {{PubMed|20201588}} |
** expressed at high cell density ([[ComA]]) {{PubMed|16091051}} | ** expressed at high cell density ([[ComA]]) {{PubMed|16091051}} | ||
| Line 124: | Line 124: | ||
=References= | =References= | ||
| − | <pubmed>12737802, 18941141, 18820022, 18384517, 17919287, 16932747,12737802 19850612 16091051</pubmed> | + | <pubmed>12737802, 18941141, 18820022, 18384517, 17919287, 16932747,12737802 19850612 16091051 20201588</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:08, 6 March 2010
- Description: repressor of fatty acid synthetic genes
| Gene name | fapR |
| Synonyms | ylpC |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of fatty acid biosynthesis |
| Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
| MW, pI | 21 kDa, 5.393 |
| Gene length, protein length | 564 bp, 188 aa |
| Immediate neighbours | recG, plsX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU15880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: FapR regulates the expression of at least 10 genes (the fap regulon). It autoregulates its own expression. Malonyl-CoA, a precursor of fatty acid biosynthesis, binds to FapR changing its conformation to a non-DNA binding state. Hence, conditions that cause malonyl-CoA accumulation, like fatty acid biosynthesis inhibition, derepress the fap regulon.
- Protein family: fapR family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: malonyl-CoA and malonyl-ACP act as the molecular inducer of the FapR regulon PubMed
- Localization:
Database entries
- UniProt: O34835
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
