Difference between revisions of "Ogt"

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=The gene=
 
=The gene=

Revision as of 14:38, 16 February 2010

  • Description: O6-methylguanine DNA alkyltransferase

Gene name ogt
Synonyms dat
Essential no
Product O6-methylguanine DNA alkyltransferase
Function DNA repair
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 18 kDa, 7.092
Gene length, protein length 495 bp, 165 aa
Immediate neighbours kinE, mtnA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Ogt context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU13540

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine (according to Swiss-Prot)
  • Protein family: MGMT family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1SFE (from E. coli, 36% identity, 51% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References