TcyL

• Description: cystine ABC transporter (permease)
  
  

Gene name	tcyL
Synonyms	ytmL
Essential	no
Product	cystine ABC transporter (permease)
Function	cystine uptake
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	26 kDa, 9.3
Gene length, protein length	717 bp, 239 aa
Immediate neighbours	tcyM, tcyK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29360

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: binding-protein-dependent transport system permease family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O34315

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytmI-tcyJ-tcyK-tcyL-tcyM-tcyN-ytmO-ytnI-ytnJ-ribR-ytnL-ytnM PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • YtlI: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: