Difference between revisions of "Fnr"
(→Extended information on the protein) |
(→Expression and regulation) |
||
| Line 89: | Line 89: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | |||
* '''Operon:''' | * '''Operon:''' | ||
| + | ** ''[[narK]]-[[fnr]]'' {{PubMed|8846791}} | ||
| + | ** ''[[fnr]]'' {{PubMed|8846791}} | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| + | ** ''[[narK]]'': [[SigA]] {{PubMed|8846791}} | ||
| + | ** ''[[fnr]]'': [[SigA]] {{PubMed|8846791}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10972836 PubMed] | + | ** ''[[narK]]'': expressed under anaerobic conditions ([[Fnr]]) {{PubMed|8846791,16428414}} |
| + | ** ''[[fnr]]'': expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10972836 PubMed] | ||
** repressed unless NO is present under anaerobic conditions ([[NsrR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed] | ** repressed unless NO is present under anaerobic conditions ([[NsrR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed] | ||
| − | + | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 104: | Line 108: | ||
** [[Fnr]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed] | ** [[Fnr]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed] | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 19:44, 3 February 2010
- Description: transcriptional regulator of anaerobic genes
| Gene name | fnr |
| Synonyms | |
| Essential | no |
| Product | transcription regulator (Crp family) |
| Function | regulation of anaerobiosis, fermentation and overflow metabolism |
| MW, pI | 27 kDa, 5.989 |
| Gene length, protein length | 714 bp, 238 aa |
| Immediate neighbours | ywiC, narK |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU37310
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Genes/ operons controlled by Fnr
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: contains an iron-sulfur cluster
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P46908
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456]
[WorldCat.org]
[DOI]
(P p)
Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414]
[WorldCat.org]
[DOI]
(P p)
M M Nakano, Y Zhu, M Lacelle, X Zhang, F M Hulett
Interaction of ResD with regulatory regions of anaerobically induced genes in Bacillus subtilis.
Mol Microbiol: 2000, 37(5);1198-207
[PubMed:10972836]
[WorldCat.org]
[DOI]
(P p)
M M Nakano, P Zuber, P Glaser, A Danchin, F M Hulett
Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilis.
J Bacteriol: 1996, 178(13);3796-802
[PubMed:8682783]
[WorldCat.org]
[DOI]
(P p)
H Cruz Ramos, L Boursier, I Moszer, F Kunst, A Danchin, P Glaser
Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms.
EMBO J: 1995, 14(23);5984-94
[PubMed:8846791]
[WorldCat.org]
[DOI]
(P p)
