Difference between revisions of "ThiM"
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| + | * '''Operon:''' ''[[ywbI]]-[[thiM]]-[[thiE]]'' {{PubMed|9139923}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9139923}} | |
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| − | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 20:43, 4 February 2010
- Description: hydroxyethylthiazole kinase
| Gene name | thiM |
| Synonyms | thiK, ipa-25d, ywbJ |
| Essential | no |
| Product | hydroxyethylthiazole kinase |
| Function | biosynthesis of thiamine |
| MW, pI | 28 kDa, 5.393 |
| Gene length, protein length | 816 bp, 272 aa |
| Immediate neighbours | thiE, ywbI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU38300
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole (according to Swiss-Prot)
- Protein family: Thz kinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure: 1C3Q
- UniProt: P39593
- KEGG entry: [3]
- E.C. number: 2.7.1.50
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578]
[WorldCat.org]
[DOI]
(I p)
Original publications
