Difference between revisions of "MrpA"

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= Categories containing this gene/protein =
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{{SubtiWiki category|[[transporters/ other]]}},
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{{SubtiWiki category|[[metal ion homeostasis (K, Na, Ca, Mg)]]}},
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{{SubtiWiki category|[[essential genes]]}},
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{{SubtiWiki category|[[membrane proteins]]}}
 
=The protein=
 
=The protein=
  

Revision as of 18:09, 30 November 2010

  • Description: Na+/H+ antiporter subunit, multiple resistance and pH homeostasis

Gene name mrpA
Synonyms yufT, shaA, ntrA
Essential yes PubMed
Product Na+/H+ antiporter subunit
Function sodium export
MW, pI 86 kDa, 9.519
Gene length, protein length 2322 bp, 774 aa
Immediate neighbours yufS, mrpB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MrpA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU31600

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), essential genes, membrane proteins

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yusuke Kajiyama, Masato Otagiri, Junichi Sekiguchi, Toshiaki Kudo, Saori Kosono
The MrpA, MrpB and MrpD subunits of the Mrp antiporter complex in Bacillus subtilis contain membrane-embedded and essential acidic residues.
Microbiology (Reading): 2009, 155(Pt 7);2137-2147
[PubMed:19389778] [WorldCat.org] [DOI] (P p)

Saori Kosono, Kei Asai, Yoshito Sadaie, Toshiaki Kudo
Altered gene expression in the transition phase by disruption of a Na+/H+ antiporter gene (shaA) in Bacillus subtilis.
FEMS Microbiol Lett: 2004, 232(1);93-9
[PubMed:15019740] [WorldCat.org] [DOI] (P p)

M Ito, A A Guffanti, W Wang, T A Krulwich
Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistance.
J Bacteriol: 2000, 182(20);5663-70
[PubMed:11004162] [WorldCat.org] [DOI] (P p)

M Ito, A A Guffanti, B Oudega, T A Krulwich
mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.
J Bacteriol: 1999, 181(8);2394-402
[PubMed:10198001] [WorldCat.org] [DOI] (P p)