Difference between revisions of "NatK"
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''Domains:''' three transmembrane segments, C-terminal histidine phosphotransferase domain |
| − | * '''Modification:''' | + | * '''Modification:''' autophosphorylation on a His residue |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| Line 70: | Line 70: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''Interactions:''' [[NatK]]-[[NatR]] |
* '''Localization:''' cell membrane (according to Swiss-Prot) | * '''Localization:''' cell membrane (according to Swiss-Prot) | ||
Revision as of 19:41, 30 November 2009
- Description: two-component sensor kinase, regulation of the natA-natB operon
| Gene name | natK |
| Synonyms | yccG |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of the natA-natB operon |
| MW, pI | 34 kDa, 8.045 |
| Gene length, protein length | 954 bp, 318 aa |
| Immediate neighbours | yccF, natR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU02730
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of NatR in response to sodium availability
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: three transmembrane segments, C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P70954
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: natK (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186]
[WorldCat.org]
[DOI]
(P p)
C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672]
[WorldCat.org]
[DOI]
(P p)
