Difference between revisions of "LicA"

From SubtiWiki
Jump to: navigation, search
(Expression and regulation)
Line 89: Line 89:
  
 
=Expression and regulation=
 
=Expression and regulation=
 +
* '''Operon:''' ''[[licB]]-[[licC]]-[[licA]]-[[licH]]'' {{PubMed|8990303}}
  
* '''Operon:''' ''[[licB]]-[[licC]]-[[licA]]-[[licH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8990303 PubMed]
+
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8990303}}
  
* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8990303 PubMed]
+
* '''Regulation:'''  
 +
** carbon catabolite repression ([[CcpA]]) {{PubMed|8990303}}
 +
** induction by oligomeric ß-glucosides ([[LicR]]){{PubMed|8990303}}
  
* '''Regulation:''' repressed by glucose ([[CcpA]]) ,  carbon catabolite repression, induction by oligomeric ß-glucosides [http://www.ncbi.nlm.nih.gov/sites/entrez/8990303 PubMed]
+
* '''Regulatory mechanism:'''  
 
+
** [[CcpA]]: transcription repression {{PubMed|8990303}}
* '''Regulatory mechanism:''' [[CcpA]]: transcription repression,  catabolite repression: repression by [[CcpA]], induction: transcription activation by the PRD-type regulator [[LicR]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8990303 PubMed]
+
** [[LicR]]: transcription activation {{PubMed|8990303}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 10:23, 6 February 2010

Gene name licA
Synonyms celC
Essential no
Product lichenan-specific phosphotransferase system,
EIIA component
Function lichenan uptake and phosphorylation
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 12 kDa, 4.641
Gene length, protein length 330 bp, 110 aa
Immediate neighbours licH, licC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
LicA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU38570

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family: PTS permease, lactose permease (Lac) family PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 3K1S (IIA(Cel) from B. anthracis, 42% identity)
  • KEGG entry: [2]
  • E.C. number: 2.7.1.69

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References