Difference between revisions of "XylR"
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| − | * '''Description:''' transcriptional repressor of the | + | * '''Description:''' transcriptional repressor of the ''[[xylA]]-[[xylB]]'' and ''[[xynP]]-[[xynB]]'' operons <br/><br/> |
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* '''Protein family:''' ROK (nagC/xylR) family (according to Swiss-Prot) | * '''Protein family:''' ROK (nagC/xylR) family (according to Swiss-Prot) | ||
| − | * '''Paralogous protein(s):''' | + | * '''Paralogous protein(s):''' [[GlcK]] |
=== Extended information on the protein === | === Extended information on the protein === | ||
Revision as of 19:10, 31 July 2010
| Gene name | xylR |
| Synonyms | |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of xylan and xylose utilization |
| Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
| MW, pI | 38 kDa, 5.819 |
| Gene length, protein length | 1050 bp, 350 aa |
| Immediate neighbours | xynB, xylA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU17590
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription repression of the xylA-xylB and the xynP-xynB operons
- Protein family: ROK (nagC/xylR) family (according to Swiss-Prot)
- Paralogous protein(s): GlcK
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: inducer: xylose
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P94490
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: xylR (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP270 (erm), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Your additional remarks
References
M K Dahl, D Schmiedel, W Hillen
Glucose and glucose-6-phosphate interaction with Xyl repressor proteins from Bacillus spp. may contribute to regulation of xylose utilization.
J Bacteriol: 1995, 177(19);5467-72
[PubMed:7559331]
[WorldCat.org]
[DOI]
(P p)
M K Dahl, J Degenkolb, W Hillen
Transcription of the xyl operon is controlled in Bacillus subtilis by tandem overlapping operators spaced by four base-pairs.
J Mol Biol: 1994, 243(3);413-24
[PubMed:7966270]
[WorldCat.org]
[DOI]
(P p)
C Kauder, R Allmansberger, D Gärtner, D Schmiedel, W Hillen
An operator binding-negative mutation of Xyl repressor from Bacillus subtilis is trans dominant in Bacillus megaterium.
FEMS Microbiol Lett: 1993, 109(1);81-4
[PubMed:8319885]
[WorldCat.org]
[DOI]
(P p)
D Gärtner, J Degenkolb, J A Ripperger, R Allmansberger, W Hillen
Regulation of the Bacillus subtilis W23 xylose utilization operon: interaction of the Xyl repressor with the xyl operator and the inducer xylose.
Mol Gen Genet: 1992, 232(3);415-22
[PubMed:1588910]
[WorldCat.org]
[DOI]
(P p)
P Kreuzer, D Gärtner, R Allmansberger, W Hillen
Identification and sequence analysis of the Bacillus subtilis W23 xylR gene and xyl operator.
J Bacteriol: 1989, 171(7);3840-5
[PubMed:2544559]
[WorldCat.org]
[DOI]
(P p)
