FolE

• Description: GTP cyclohydrolase I
  
  

Gene name	folE
Synonyms	mtrA
Essential	no
Product	GTP cyclohydrolase IA
Function	biosynthesis of folate
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp, Folate
MW, pI	21 kDa, 6.335
Gene length, protein length	570 bp, 190 aa
Immediate neighbours	mtrB, hbs
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU22780

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: GTP + H₂O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

• Protein family: citrate synthase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): zinc-dependent enzyme PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3D2O (enzyme from Neisseria gonorrhoeae) PubMed

• UniProt: P19465

• KEGG entry: [3]

• E.C. number: 3.5.4.16

Expression and regulation

• Operon: folE-mtrB PubMed

• Sigma factor: SigA PubMed

• Regulation: constitutive PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: