Difference between revisions of "RapC"

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|style="background:#ABCDEF;" align="center"| '''Product''' || response regulator aspartate phosphatase
 
|style="background:#ABCDEF;" align="center"| '''Product''' || response regulator aspartate phosphatase
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of sporulation initiation
+
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[ComA]] activity
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 45 kDa, 5.024   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 45 kDa, 5.024   
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' control of [[ComA]] activity {{PubMed|12950917}}
  
 
* '''Protein family:''' RAP family (according to Swiss-Prot)
 
* '''Protein family:''' RAP family (according to Swiss-Prot)
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* '''Cofactor(s):'''
 
* '''Cofactor(s):'''
  
* '''Effectors of protein activity:'''
+
* '''Effectors of protein activity:''' binding of [[PhrC]] to [[RapC]] prevents it from binding [[ComA]] {{PubMed|12950917}}
  
* '''Interactions:''' [[RapC]]-[[PhrC]],  [[RapC]]-[[ComA]]
+
* '''Interactions:''' [[RapC]]-[[PhrC]] {{PubMed|12950917}},  [[RapC]]-[[ComA]] {{PubMed|12950917}}
  
 
* '''Localization:'''
 
* '''Localization:'''

Revision as of 08:03, 29 November 2009

  • Description: response regulator aspartate phosphatase

Gene name rapC
Synonyms yclL
Essential no
Product response regulator aspartate phosphatase
Function control of ComA activity
MW, pI 45 kDa, 5.024
Gene length, protein length 1146 bp, 382 aa
Immediate neighbours yclK, phrC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RapC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU03770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: control of ComA activity PubMed
  • Protein family: RAP family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: binding of PhrC to RapC prevents it from binding ComA PubMed
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Leighton Core, Marta Perego
TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis.
Mol Microbiol: 2003, 49(6);1509-22
[PubMed:12950917] [WorldCat.org] [DOI] (P p)

B A Lazazzera, I G Kurtser, R S McQuade, A D Grossman
An autoregulatory circuit affecting peptide signaling in Bacillus subtilis.
J Bacteriol: 1999, 181(17);5193-200
[PubMed:10464187] [WorldCat.org] [DOI] (P p)