Difference between revisions of "ComS"

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** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}}  
 
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}}  
 +
** expressed at high cell density ([[ComA]]) {{PubMed|16091051}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
** [[ComA]]: transcription activation {{PubMed|1715856}}  
+
** [[ComA]]: transcription activation {{PubMed|1715856,16091051}}  
 
** [[PerR]]: transcription activation {{PubMed|16166527}}
 
** [[PerR]]: transcription activation {{PubMed|16166527}}
  
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<pubmed>  19609260 </pubmed>
 
<pubmed>  19609260 </pubmed>
 
==Original Publications==
 
==Original Publications==
<pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 1715856</pubmed>
+
<pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 1715856 16091051</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:49, 15 February 2010

  • Description: antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway

Gene name comS
Synonyms
Essential no
Product antiadaptor protein (anti-MecA)
Function control of ComK degradation
MW, pI 5 kDa, 9.145
Gene length, protein length 138 bp, 46 aa
Immediate neighbours srfAB, srfAC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComS context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU03500

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed during hydrogen peroxide stress (PerR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260] [WorldCat.org] [DOI] (I p)

Original Publications